Tampilkan postingan dengan label Psychiatry. Tampilkan semua postingan
Tampilkan postingan dengan label Psychiatry. Tampilkan semua postingan

Selasa, 21 Maret 2017

Anecdotal Evidence and Inductive Conclusions in Psychiatry Part II



Cherry picking: pointing to individual cases or data that seem to confirm a particular position, while ignoring a significant portion of related cases or data that may contradict that position


In part I of this post, I discussed the issue of inductive reasoning, and how it can be a source of quite valid scientific evidence. This brings up the question of what is a valid conclusion based on inductive reason versus an invalid conclusion based on one person’s personal experience.

The following comes from my book, How Dysfunctional Families Spur Mental Disorders.

Anecdotal evidence in medicine is often misleadingly defined as evidence based on only one clinician’s personal experience with a treatment or diagnosis in question. If that is the standard that is to be used, clearly many reasons exist to question the validity of inferences drawn from these experiences. Individuals are well known to have various biases that color their observations and the conclusions they draw from them. 

They may have blind spots because of their own emotional conflicts. They may ignore evidence that is contradictory to their point of view. Their observations may be limited by their pet theories about the phenomena in question. 

Perhaps even more importantly, they may be seeing unusual cases that are not representative of more “typical” cases in one way or another – a so-called selection bias.

An obvious case of selection bias was illustrated by a statement I heard made at a conference by a family therapy pioneer, the late Jay Haley. I had always admired Mr. Haley for many of his fascinating and utilitarian ideas and observations. However, in this case he betrayed some ignorance. He stated that he did not believe antidepressant drugs were ever effective because none of the patients referred to him had ever responded to them.

Of course, his being a well-known family therapist who did not believe in medication had a tremendous effect on exactly who would be referred to him. Not everyone does respond to drug treatment. Anyone who had responded to an antidepressant would, in all probability, rarely if ever darken his door. Hence, with his sample, he would be misled into thinking that the medicines were not effective for anybody. This form of bias is very common and can be quite subtle. For example, it can affect one’s beliefs about such matters as racial stereotypes or a determination of how trustworthy members of a city’s police department are.

Do these types of biases invalidate all clinical experience? Hardly. First of all, we have to distinguish between the descriptions of the actual events contained within specific anecdotes, and the conclusions or inferences which are drawn from these events. 

Let us first examine the descriptionsof what actually happened. A specific anecdote may be accurately observed and described, or not so accurately. If important details are altered or left out entirely, the anecdote may indeed be worthless. However, the exact same thing can be said about empirical studies.

Important details may not even be known to an observer. Particularly with observations of family behavior within a practitioner’s or researcher’s office, important information is almost always hidden, either by design or unwittingly. In addition to the fact that one does not see the whole picture in any single context, there is also a basic problem inherent in the nature of interactions between intimates.

With verbal behavior, for instance, linguists refer to a quality called ellipsis. What this means is that in conversations among people who have known each other for a while, certain information is not spelled out verbally because the other person already knows it. Strangers such as therapists who are listening in and who have not been privy to these prior experiences may think they know what the family is talking about, but they may in reality be completely clueless.

Let us now consider the separate issue of conclusions that are drawn from anecdotes, as opposed to their description. The questions raised by an accurately-described clinical observation can be quite valid, but the answers inferred from it can be completely wrong. Conclusions based on clinical “anecdotes” exist on a continuum from relatively accurate ones to those that are extremely biased to those that are based on spectacular inferential or logical leaps of faith.

Relatively unbiased clinical conclusions based on anecdotes by mental health professionals have many things in common: 

·   They are based on a sample that one has a reasonable expectation is at least somewhat representative of a larger population.

·    They make use, not just the practitioner’s observations, but of the observations of other professionals whom one knows to be reliable and open minded. These clinicians should also be ones known to take the time with their patients necessary to take a complete history. Widespread clinical experience by competent clinicians is something upon which someone can make a very valid inductive conclusion, and is not just “anecdotal evidence.” In fact, conclusions drawn from this source tend to be more accurate that those drawn from so called “empirical” studies. Many dangerous side effects from drugs that did not show up in the initial drug studies have been discovered in this manner.
  
·     They make use of other informants besides the patient when possible.

·     They take into consideration that people and their family members behave quite differently behind closed doors than they do in public, and therefore if at all possible include observations of patient behavior when patients are unaware that they are being observed.

·    They are based on longitudinal observations. That is, the patients on whom conclusions are based have been seen on multiple occasions over an extended period of time.

·     They are not contradicted by commonly observed examples of behavior in everyday life related to the behavior in question.

·      The person proposing the conclusion acknowledges potential biases, such as a financial stake in a certain drug or allegiance to a specific school of therapy, and acknowledges his or her limitations. What former president of the Society of Clinical Psychology, Gerald C. Davison, calls “ex cathedra statements based upon flimsy and subjective evidence,” a hallmark of some psychotherapy gurus, are always highly suspicious. In fact, charlatans are relatively easy to spot. They have a tendency to sidestep challenges. I will give an example of this shortly.
  
·     The conclusions reached should lead to predictions of patient behavior under certain circumstances that prove to be accurate in a significant number of cases. This is called predictive validity. Of course, human behavior being as unpredictable as it is, at times the predictions will not be completely accurate even if the conclusions are valid, and so this fact must also be taken into account.

·     Conclusions based on anecdotes about treatment efficacy or the reasons for certain observed behavior should consider several alternate possible explanations for the observations. If several explanations are possible, one must make a judgment about which ones are more likely and which are less likely based not on the anecdote alone, but on all sources of data available. These sources include empirical studies, but also include observations from everyday life, as well as material seen in some relatively reliable media such as reputable newspapers.

Now of course stories in the media also do not tell the whole story or may be biased, so one needs to realize again that one can be fooled, and take this into account as well. I used to believe the common myth, for example, that in nature under certain conditions the animals called lemmings would follow each other off a cliff and commit mass suicide.

I was surprised when I learned that this was untrue because I had as a child in 1958 seen a film clip of said mass suicide that was part of a Disney “True Life Adventure” nature movie called White Wilderness. I later learned that, because the Disney crew could not find a real example, they had from behind the scenes driven the group of lemmings off the cliff for the cameras.

On the other hand, many people believe that men have never been to the moon and that films of the moon landings were made in a movie studio using special effects. I must say, I tend to believe that those film clips are real, but few know for certain.

·   If other anecdotes about similar patients and treatments seem to contradict the conclusions based on a given anecdote, an attempt should be made to account for this difference.

As an illustration of the latter point and an example of a the “quick step side step” in scientific presentations. I once heard an expert present new evidence from neuroscience that certain capabilities of which human brains are capable seem to develop only at certain times during early childhood development. This brain development could be adversely affected by a baby’s early social environment. Of course, that is somewhat true.

Like psychoanalysts will, however, the expert went on to conclude that if the adverse early experiences had taken place, the child had no chance of growing up to be normal. I raised my hand and asked about those children who come from horribly adverse backgrounds, are adopted away at an age past the alleged crucial developmental time, and yet still turn out wonderfully. The expert then changed the subject without ever addressing my question.  

If the data doesn't fit your pre-conceived conclusions, just change the subject!

Remember, there are NO empirical, placebo-controlled, double blind controlled studies on whether parachutes reduce the incidence of deaths or injuries after falling out of airplanes. Or that appendectomies are effective in preventing complications and deaths from appendicitis. And yet we all take those things for granted.

Rabu, 01 Maret 2017

More Astonishing Cutting Edge Research in Psychiatry



As we did on my post of November 30, 2011, it’s once again time to look over the highlights from my two favorite medical journals, Duh! and No Sh*t, Sherlock. 

As I pointed out in that post, research dollars are very limited and therefore precious.  Why waste good money trying to study new, cutting edge or controversial ideas that might turn out to be wrong, when we can study things that that are already thought to be true but have yet to be "proven"?  Such an approach increases the success rate of studies almost astronomically.

Psychiatric blogger Nassir Ghaemi agrees: "In some estimates, less than 10% of all NIMH funding is aimed at clinically relevant treatment research on major mental illnesses (i.e., schizophrenia or bipolar disorder). Further, that limited funding is sparingly distributed: the highly conservative, non-risk-taking nature of NIH peer review is well-known."

Here are some of the most interesting new findings reported in these journals.

Side Effects and Therapeutic Effects Are Not The Same Thing

A brilliant new study (http://www.reuters.com/article/2011/12/08/us-depressed-worse-idUSTRE7B72JM20111208) on one anti-depressant concluded: "In the first few months patients either responded to the treatment and improved or didn't and still suffered side effects." Really? People can get side effects from a drug but no benefit? That actually happens?!? I never knew.

Teen Pregnancy Associated with Poverty, Low Education

The Charleston (WV) State Journal (3/27, Burdette) reports that "a report released last week by Auburn University shows that the high poverty levels and low educational attainment among women have a direct correlation to the region's high number of teen births." The media is so irresponsible! Why haven't they pointed out this correlation more often than the previous 13,000 time?


Deployment, not Military Service, Stresses Reservists

What?  Combat is more stressful than merely serving in the military??  But it looks like so much fun.

Listening to Loud Music Associated with Substance Abuse

The Los Angeles Times (5/22, Kaplan) "Booster Shots" blog reports that according to a study published online May 21 in the journal Pediatrics, "Teens and young adults who listen to digital music players with ear buds are almost twice as likely as non-listeners to smoke pot.” As a veteran of the San Francisco music scene in 1967, I just never noticed that the people in the audience at the Fillmore auditorium were smoking pot. I always thought that smell came from the incense they were burning, and that those funny cigarettes were just home-rolled tobacco. Additionally, their LSD use was greatly exaggerated. They were not hallucinating. Those light shows were just really amazing.

And on a related note:

Small Study: Medical Marijuana May Impair New Patients' Driving Skills.

Reuters (7/27, Pittman) reported that although it often goes unnoticed during sobriety tests, the use of medical marijuana at the typical doses used by AIDS, cancer and chronic pain patients causes users who have not yet built up a tolerance to cannabinoids to totter from side-to-side when driving, according to a study published online July 12 in the journal Addiction.  Well I’ll be!  Intoxicants impair driving skills?  Who knew?  Legislatures should look into doing something about this, or someone could get killed.

 Review: Negative Interactions with Staff Common Cause of Aggression on Psychiatric Wards

MedWire (5/26, Cowen) reported, "Negative interactions with staff are the most common cause of aggression and violence among inpatients in adult psychiatric settings," according to a review published in the June issue of the journal Acta Psychiatrica Scandinavica. Now come on!! Patients with schizophrenia are just naturally aggressive. It’s in their genes! Don’t let their completely flat affect and their total inability to organize a break out from a locked ward fool you.

Parental Fighting May Lead to Later Depression, Anxiety in Children

 

HealthDay (6/16, Goodwin) reported that "slamming doors, shouting and stony silences between mom and dad can really scar kids emotionally," according to a study published in the journal Child Development. Investigators found that "Kindergarteners whose parents fought with each other frequently and harshly were more likely to grow into emotionally insecure older children who struggled with depression, anxiety and behavior issues by 7th grade."  Here we go again. This parent bashing has just got to stop. We all know very well that behavior is controlled by genes and that environmental stress has absolutely zero psychological consequences.

And as long as we are on the subject of parent bashing, here’s some more evidence for this horrible trend:

Children's Adherence to Mental-Health Treatment May Depend on Parents' Perceptions

 

MedPage Today (8/4, Petrochko) reported, "Whether or not a child maintains a treatment for mental health may depend on parents' perceived benefits of that treatment," according to a 573-participant study published in the August issue of the journal Psychiatric Services. How many times can I stress this?  Parenting skills are absolutely irrelevant in determining the behavior of their children.